Anaphylactic shock induced by diclofenac.
نویسندگان
چکیده
Diclofenac is a non-steroidal anti-inflammatory agent used in degenerative joint disease, rheumatoid arthritis, and allied conditions.' Its commonest unwanted effects include gastrointestinal disorders, rashes, peripheral oedema, and abnormalities of serum transaminase activity. More rarely, melaena and haematemesis, myoclonic encephalopathy, and myoclonus of the lower limbs may occur.2 3 We report a case of anaphylactic shock induced by diclofenac, which as yet is an unreported complication of treatment with this agent.
منابع مشابه
Anaphylaxis to diclofenac: nine cases reported to the Allergy Vigilance Network in France.
Nine cases of diclofenac hypersensitivity recorded by the Allergy Vigilance Network in France from 2002 to 2012 were studied. Data from history, symptoms, skin tests, basophil activation tests, and oral challenge (OC) were recorded. Grade 3 severe anaphylactic reactions occurred in seven cases of nine. IgE-dependent anaphylaxis was confirmed in six cases: positive intradermal tests (n = 4), a s...
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Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a virulent molecule specific for tachyzoites of T. gondii. The expression of T.g.HSP70 rapidly increases just before death of the host, indicating that T.g.HSP70 functions as a danger signal during lethal acute T. gondii infection. In the present study, T.g.HSP70 was proven to be capable of inducing lethal anaphylactic reaction in T...
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REFERENCES 1. Szczeklik A. Adverse reactions to aspirin and nonsteroidal antiinflammatory drugs. Ann Allergy 1987;59:113-18. 2. Alkhawajah AM, Eifawai M, Mahmoud SF Fatal anaphyiactic reaction to diclofenac. Forensic Sci Int 1993;60:107-10. 3. Mescheder A, Nokhodian A, Kirch W. Anaphylactic shock as complication of Ml application of diclofenac. Arzneimitteltherapie 1993;11:237-9. 4. Romano A, P...
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ورودعنوان ژورنال:
- British medical journal
دوره 286 6381 شماره
صفحات -
تاریخ انتشار 1983